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| NEW! InhibitorSelect™ Protein Kinase Library I (Cat. No. 539744) |
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| Contains 80 well-characterized, potent protein kinase inhibitors in a convenient 96-well plate format supplied at a concentration of 10 mM in DMSO. |
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| The InhibitorSelect™ Protein Kinase Library I contains multiple inhibitors against four of the main kinase groups, including tyrosine kinases, TKL (tyrosine-kinase-like), AGC (containing PKA, PKG, and PKC families), and CaMK (calcium/calmodulin-dependent protein kinase). |
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Akt | AMPK | Aurora | Bcr-Abl | DNA-PK | EGFR | FLT3 | FMS | IGFR | IRAK | JAK | Lck | Met | PDGFR | PI 3-K | PKC | Rho | Src | Syk | TGF-b R | VEGFR |
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| Convenient for... |
| Target identification in drug discovery | | | • | Screen for small molecule inhibitors that block receptor mediated signal transduction | | Biochemical pathway analysis | | | • | Screen small molecule inhibitors that may affect either upstream or downstream targets | | Screening of new protein kinases | | | • | Profile against inhibitors with known biological activity and structure | | Other pharmaceutical applications | | | • | Useful for cell phenotypic screening | | Cell-based assays |
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| Advantages of InhibitorSelect™ Protein Kinase Library I |
Highest Quality Control - Purity of every inhibitor solution is tested by HPLC (≥95%). Lot specific data for every inhibitor in solution is provided.
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Format
- Convenient 96-well, polypropylene, non-pyrogenic black V-bottom microplate
- Corning™ 96-well robolid microplate seal
- provides individual silicone seal for each well of plate with resiliency for DMSO
- protects DMSO solutions from moisture
- avoids cross contamination
- can be applied and removed a number of times
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| Inhibitors | | - Cell-permeable for use in cell based-assays
- ATP-competitive
- Stable in DMSO
- 50 ml/well
- Structurally diverse selection
- Multiple inhibitors against selected targets
- Potent, with well-established biological activities
- Individual inhibitors are available in larger quantities
| | Comprehensive Documentation | - Structure Data Files (SDF)
- Published IC50 values
- CAS Numbers
- Literature Citations
- PubChem Compound ID (where available)
- Inhibitor Description
- Molecular weight
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