Pseudoproline dipeptides are undoubtedly the most powerful tools described to date for enhancing synthetic efficiency in Fmoc SPPS.

The routine use of pseudoproline dipeptides has been found to:

• help avoid costly and unnecessary repeat syntheses of failed sequences;
  
• increase purity of crude products;
  
• simplify HPLC purification;
  
• increase yield of crude and purified products;
  
• enable synthesis to be carried out on a lower scale.

How do they work?

Guidelines for use of pseudoproline dipeptides

Pseudoproline Resources

List of pseudoproline dipeptides available from Novabiochem