| Product | Cat. No. | Target Protease Class and Mechanism of Action | Solubility | Suggested Concentration | | AEBSF, Hydrochloride | | Water soluble, non-toxic alternative to PMSF. Irreversible inhibitor of serine proteases. Reacts covalently with a
component of the active site. Inhibits chymotrypsin, kalikrein, plasmin, trypsin and related thrombolytic enzymes. | H2O | 0.1-1 mM | | ALLN | | Inhibits calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), Cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 600 pM). | Methanol,
Ethanol,
DMSO | 0.2-2 mM | | Aprotinin, Bovine Lung | | A serine protease inhibitor that acts as a competitive and reversible inhibitor of proteolytic and esterolytic activity. In cell cultures, extends the life of cells and prevents proteolytic damage to intact cells. | H2O | 0.6-2.0 mg/ml | | Aprotinin, Recombinant | | A serine protease inhibitor that acts as a competitive and reversible inhibitor of proteolytic and esterolytic activity. In cell cultures, extends the life of cells and prevents proteolytic damage to intact cells. | H2O | 0.6-2.0 mg/ml | | Bestatin | | Binds to cell surfaces and inhibits cell surface aminopeptidases, notably aminopeptidase B and leucine
aminopeptidase. Activates macrophages and T lymphocytes. Has antitumor properties. | Methanol | 1-10 mM | | Cathepsin Inhibitor I | | Selectively inhibits cathepsin B (k2/Ki = 6.9 x 103 M-1 sec-1), cathepsin L (k2/Ki = 3.1 x 105 M-1 sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1 sec-1), and papain (k2/Ki = 1.8 x 103 M-1 sec-1). | DMSO,
Ethanol | 100-200 mM | | E-64 Protease Inhibitor | | An irreversible cysteine protease inhibitor that has no action on cysteine residues in other proteins. Specific active site titrant. | H2O, DMSO | 1-10 mM | | EDTA, Disodium Salt, Molecular Biology Grade | | A reversible metalloprotease inhibitor. A chelator that may interfere with other metal ion-dependent biological
processes. | H2O | 1-10 mM | | Elastatinal | | A competitive inhibitor of elastase (Ki = 240 nM). | H2O, DMSO,
Ethanol | 0.5-2 mg/ml | | EST | | A membrane-permeable calpain inhibitor. | Ethanol | 20-50 mg/ml | | GGACK | | An irreversible inhibitor of Urokinase (IC50 < 1 mM). | H2O | 1-10mM | | Leupeptin, Hemisulfate | | A reversible inhibitor of trypsin-like proteases and cysteine proteases, including endoproteinase Lys-C, papain, cathepsin B, trypsin, kallikrein, and thrombin. | H2O | 10-100 mM | | Pepstatin A | | A reversible inhibitor of aspartic protease. Inhibits cathepsin D, cathepsin G, pepsin, and renin. | DMSO,
Methanol | ~ 1 mM | | o-Phenanthroline | | A metalloprotease inhibitor. | DMSO,
Ethanol, H2O | | | Phosphoramidon, Disodium Salt | | A highly specific inhibitor of thermolysin. Also inhibits the conversion of big endothelin-1 to endothelin-1. | H2O, DMSO,
Methanol | 1-10 mM | | TLCK, HCl | | An irreversible inhibitor of trypsin-like serine proteases. Inactivates trypsin, specifically and irreversible. Does not
have any significant inhibitory effect on chymotrypsin. | H2O | 10-100 mM | | TPCK | | An irreversible inhibitor of chymotrypsin. Useful for inhibiting
chymotrypsin activity in trypsin preparations. | Ethanol,
Methanol | 10-100 mM |
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