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Apoptosis: Granzyme Inhibitors
 | | | | The lytic enzymes of cytotoxic lymphocytes seem to be contained within lysosome-like granules found in the cytoplasm. These granules contain perforin, a membrane pore-forming protein, and a family of serine proteases (granzymes). Granzyme B, a 32 kDa protein, is a serine caspase associated with the granules of Natural Killer (NK) cells. Granzyme B seems to be able to elicit cell death, perhaps by activating an endogenous pathway of programmed cell death. | | | | Table 1: Selected Granzyme Inhibitors | Products | | | | | | | | Granzyme B Inhibitor II | | 502.5 | Ac-IETD-CHO† | - | √ | Granzyme B, Caspase-8 | | Granzyme B Inhibitor II, Cell-permeable | | 2000.4 | Ac-AAVALLPAVLLALLAP-IETD-CHO | √ | √ | Granzyme B, Caspase-8 | | Granzyme B Inhibitor III (See also Cat. No. 218840) | | 654.7 | Z-IE(OMe)TD(OMe)-FMK‡ | √ | - | Granzyme B, Caspase-8 | | Crm A Recombinant | | 38,000 | - | - | | Granzyme B, Caspase-1 | | Granzyme B Inhibitor I | | 441.9 | Z-AAD-CMK | √ | - | Granzyme B | | Granzyme B Inhibitor IV | | 498.5 | Ac-IEPD-CHO† | - | √ | Granzyme B, Caspase-8 |
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| Caspase-8 Inhibitor II |
218759 |
| InSolution™ Caspase-8 Inhibitor II |
218840 |
| Caspase-8 Inhibitor I, Cell-Permeable |
218773 |
| CrmA, Recombinant |
PF122 |
| 3,4-Dichloroisocoumarin |
287815 |
| FUT-175 |
344960 |
| Granzyme B Inhibitor I |
368050 |
| Granzyme B Inhibitor II |
368055 |
| Granzyme B Inhibitor IV |
368056 |
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