Product | Conc. Provided | Comments | Cat. No. |
| InSolution™ OM99-2 | 1 mM in DMSO | Inhibits human brain memapsin 2 (Ki = 1.6 nM, recombinant memapsin 2; Ki = 9.58 nM, recombinant pro-memapsin 2) and cathepsin D (Ki = 48 nM). | |
| InSolution™ g-secretase Inhibitor IX (DAPT) | 25 mM in DMSO | A cell-permeable dipeptide that suppresses ab production by blocking g-secretase (Abtotal IC50 = 115 nM, Ab42 IC50 = 200 nM). | |
| InSolution™ g-secretase Inhibitor X (L-685,458) | 1 mM in DMSO | A potent inhibitor of g-secretase (AbtotalIC50 = 17 nM, Ab40IC50 = 48 nM, and Ab42IC50 = 67 nM in SH-SY5Y cells overexpressing spbA4CTF). | |
| InSolution™ g-secretase Inhibitor XVII (WPE-III-31C) | 5 mM in DMSO | A transition-state analog inhibitor of g-secretase (IC50 = 300 nM for A b production in intact cells). | |
| InSolution™ g-secretase Inhibitor XIX | 5 mM in DMSO | A highly potent g-secretase inhibitor (IC50 = 60 pM towards Ab40 secretion in SH-SY5Y cells overexpressing spbA4CTF). | |
InSolution Inhibitors by Research Area 