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Neurobiology/Neurodegeneration: Amyloidogenesis Inhibitors | | | | Ab (b-amyloid) peptide is a major component of neuritic plaques and cerebrovascular amyloid deposits in the brains of patients with Alzheimer’s disease (AD). The cellular origin of amyloid precursor protein (APP) that gives rise to Ab is now well understood. Morphological evidence suggests that APP-immunoreactive neurites, often capped by Ab deposits, are one of the major sources of parenchymal amyloid. However, other cells, including astroglia, microglia, and vascular cells, may contribute to the formation of Ab. A long-standing hypothesis has been that Ab deposits are neurotoxic and are causative factors in the development and progression of AD. Hence, the development of inhibitors of Ab fibrillogenesis has become an important area of research. | | | | | | Inhibitors: Amyloidogenesis | |
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