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Other Inhibitors: KSP/Eg5
 | | | | Eg5, a conserved member of the kinesin-5 subclass of kinesins, controls the assembly and organization of mitotic spindles. Eg5 targets spindles by binding to two microtubules and cross bridging them. Activity of Eg5 is regulated by phosphorylation by Cdk1 and Aurora A. Phosphorylation is required for Eg5 recruitment to centrosomes. Inhibitors of Eg5 have emerged as a new class of agents that utilize the energy of ATP and destabliize microtubules.. Similar to microtubule inhibitors, Eg5 inhibitors induce mitotic arrest and trigger apoptosis. Hence, Eg5 inhibitors could have potential anti-tumor activity and may potentially be used to overcome any Taxol resistance during chemotherapy. Common features: - Cell-permeable
- Selective
- Rapidly induce monoasters formation and cell death
- Display antimitotic properties
| | | | Inhibitors: KSP/Eg5 | |
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