Dactinomycin Lyophilized. PROTECT FROM LIGHT. HYGROSCOPIC. Anti-neoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. At higher concentrations, DNA polymerase is inhibited. Also acts as a competitive inhibitor of serine proteases. Inhibits cell growth and colony formation in synchronized HeLa cells. Induces apoptosis in many cell lines. However, actinomycin D has also been shown to suppress etoposide-induced apoptosis in PC12 cells. Note: 1 set = 20 x 200 µg. Purity: ≥98% by HPLC. Stability: heat resistant and stable between pH 2 and 11. Decomposed by strong acids and bases. RTECS AU1575000, CAS 50-76-0. Merck Index: 14, 2800
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R: 28; S: 28-36/37-45 |
