3-Methyladenine White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675) Purity: ≥98% by TLC. CAS 5142-23-4. Ref.: Canu, N., et al. 2005. J. Neurochem. 92, 1228. Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845. Beugnet, A., et al. 2003. Biochem. J. 372, 555. Eskelinen, E.L., et al. 2002. Traffic 3, 878. Petiot, A., et al. 2000. J. Biol. Chem. 275, 992. Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889. |
