5-[(4-fluorobenzoyl)amino]-2-[(4-fluorobenzyl)thio]-1,3,4-thiadiazole Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (Ki = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr245 phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571. Purity: ≥97% by HPLC. Ref.: Radi, M., et al. 2008. Bioorg. Med. Chem. Lett. 18, 1207. |
