5-Chloro-7-iodo-8-hydroxyquinoline Solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid’s ability to clump together, apparently by trapping the Cu2+ and Zn2+ that stud these deposits. Shown to increase distal dominant axonopathy in animal models. Purity: ≥95% by HPLC. RTECS VC5075000, CAS 130-26-7. Merck Index: 14, 5031
Ref.: Melov, S. 2002. Trends Neurosci. 25, 121. Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord. 12, 408. Helmuth, L., et al. 2000. Science 290, 1273. Tateishi, J., et al. 2000. Neuropathology 20, Suppl: S20-4.
R: 42/43-63; S: 26-36 |
