2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC50 = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC50 ≤40 µM) and induce chromatin condensation in HeLa cells. Purity: ≥97% by HPLC. Ref.: Costi, R., et al. 2007. J. Med. Chem. 50, 1973. |
